منابع مشابه
Overexpression of stomatin depresses GLUT-1 glucose transporter activity.
We showed previously that GLUT-1 glucose transporter is associated with stomatin (band 7.2b) in human red blood cell membranes and in Clone 9 cells. We show here that in a mixed population of stably transfected cells, overexpression of either murine or human stomatin resulted in 35-50% reduction in the basal rate of glucose transport. Moreover, there was a correlation between increased expressi...
متن کاملPrognostic implications of glucose transporter protein-1 (glut-1) overexpression in bone and soft-tissue sarcomas.
BACKGROUND The glucose transporter protein 1 (Glut-1) overexpression is associated with poor overall survival (OS) in various malignant tumors. The aim of this study was to investigate prognostic significance of Glut-1 overexpression in patients with bone and soft-tissue sarcomas. METHODS A total of 67 patients (mean age, 43 years; range, 8-79 years) with bone and soft tissue sarcomas were an...
متن کاملGLUT-1 overexpression as an unfavorable prognostic biomarker in patients with colorectal cancer
BACKGROUND Glucose transporter-1 (GLUT-1) exhibits altered expression in colorectal cancer (CRC). The aim of this study was to explore the association between GLUT-1 and survival conditions, as well as clinical features in CRC by meta-analysis. MATERIALS AND METHODS Relevant studies were searched through predefined strategies, hazard ratios (HRs), odds ratios (ORs), and their 95% confidence i...
متن کاملGLUT-1 overexpression: Link between hemodynamic and metabolic factors in glomerular injury?
Mesangial matrix deposition is the hallmark of hypertensive and diabetic glomerulopathy. At similar levels of systemic hypertension, Dahl salt-sensitive but not spontaneously hypertensive rats (SHR) develop glomerular hypertension, which is accompanied by upregulation of transforming growth factor beta1 (TGF-beta1), mesangial matrix expansion, and sclerosis. GLUT-1 is ubiquitously expressed and...
متن کاملAntisense GLUT-1 protects mesangial cells from glucose induction of GLUT-1 and fibronectin expression.
A stable clone of rat mesangial cells expressing antisense GLUT-1 (i.e., MCGT1AS cells) was developed to protect them from high glucose exposure. GLUT-1 protein was reduced 50%, and the 2-deoxy-[(3)H]glucose uptake rate was reduced 33% in MCGT1AS. MCLacZ control cells and MCGT1 GLUT-1-overexpressing cells were used for comparisons. In MCLacZ, 20 mM D-glucose increased GLUT-1 transcription 90% v...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2003
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000075949.19968.ef